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What is Cushing Disease?


The average age of horses with Equine Cushing disease is 19 years old with a range of 7 to 40 years. There is no sex predisposition but ponies appear to develop the disease more frequently.


Equine Cushing Disease results from the Pituitary Gland (P) (localised below the brain) that secrets abnormally high level of adrenocorticotropin (ACTH). The ACTH then stimulates the production of cortisol by the adrenal glands (A), localised next to the kidney (K). The cortisol then enters will the blood stream (B) and causes clinical signs like laminitis.


Clinical signs

Equine Cushing Disease results from the Pituitary Gland (P) (localised below the brain) that secrets abnormally high level of adrenocorticotropin (ACTH). The ACTH then stimulates the production of cortisol by the adrenal glands (A), localised next to the kidney (K). The cortisol then enters will the blood stream (B) and causes clinical signs like laminitis.


Among the wide variety of clinical signs associated with Equine Cushing Disease, the most common is hirsutism (long and curly hair coat), reported in 85% of cases. In addition to the long shaggy hair coat, that is not shed, a variety of other hair coat abnormalities can occur. For instance early signs of Equine Cushing Disease can be delayed shedding in the spring usually followed by an early re-growth of winter coat in the autumn.

Repeated bouts of laminitis are commonly observed. Excess in circulating cortisol is thought to be linked to this manifestation. Pain secondary to laminitis represents the leading cause of euthanasia in horses with Equine Cushing Disease.


Body condition is often good; however some horses with Equine Cushing Disease even exhibit a “cresty neck” and obese appearance. As the disease progresses, weight loss, muscle wasting and muscle weakness become apparent and lead to the typical “pot belly” appearance. The occurrence of poor body condition at the later stage of the disease is often potentiated by internal parasitism and poor appetite secondary to dental disorders.


Horses with Equine Cushing Disease are predisposed to chronic infections and delayed wound healing. Lethargy, an increase in the amount of water drunk and an increase in the volume of urine produced are also commonly reported.


Treatment:

The most commonly used drug for the treatment of Equine Cushing Disease is a dopamine agonist called “Pergolide”. Pergolide has been shown to decrease the secretion of ACTH by the Pituitary Gland. Clinical improvement has been noted in 90% of horses treated after several weeks however the treatment generally needs to be continued until the end of the life of the horse. We therefore recommend taking a follow up blood sample after 4 to 6 weeks of treatment to adjust the dosage if necessary. Side effects of Pergolide treatment rarely occur however anorexia and mild colic have been reported. If your horse develops any of these side effects the vet should be contacted immediately and the treatment adjusted accordingly.


The treatment of Equine Cushing Disease should include careful health management and preventive medicine. Particular attention should be paid to diet, vaccination, deworming, hoof trimming, good dental care and prompt response to infection. Horses with long hair coat should be clipped during the warm season. In addition, because of their decreased ability to acclimatize to temperature variations they should be provided with rugs during the cold season. Good quality feed, easily chewable for horses with poor dentition, is important. On the other hand, overfeeding should be avoided as it would increase the risk of laminitis on a horse already predisposed to it. Laminitis is probably the most difficult complication to deal with, however, it appears that Pergolide for Equine Cushing Disease brings a substantial improvement in patient comfort and decreases the likelihood of further bouts of laminitis.


If you have any further question please do not hesitate to contact us on


0115 989 9411
.




by Home Farm Equine 06 Oct, 2021
SYMPTOMS The typical signs of strangles include: • Sudden high temperature and loss of appetite. • Cough. • Slight yellowy nasal discharge. • Swollen lymph nodes (glands) under the jaw and in the throat: never present in the early stages of the disease. • Rupture of the abscesses in the affected lymph nodes. Horses usually recovered fully and naturally after the rupture of the abscesses. Once the horse has recovered from strangles it usually develops a strong immunity and it is rare for an animal to be affected more than once. If your horse shows any of these symptoms it is important that you contact your vet to help confirm the diagnosis as soon as possible. A blood test and/or nasal swab can be taken to determine if you horse does have strangles. We will then be able to guide and help you with the treatment and management of your horse for their quicker recovery and also to prevent an outbreak of the disease. DIAGNOSIS The time between infection and development of clinical signs varies but it is usually 1 to 2 weeks. Strangles is diagnosed primarily on the clinical signs which may be strongly suggestive of its involvement. Nasal swabs samples can be taken for laboratory investigation. Recently a blood test has been developed which is able to tell us whether the horse has had contact with strangles in the recent past. A negative result for strangles in the swab or the blood do not guarantee that the horse does not have strangles, but these laboratory results together with the symptoms can be very helpful in determining if the horse is affected and which horses may be involved when an outbreak occurs in the yard. Some horses can become carriers, where they do not suffer the disease but they can spread it to other horses.
by Home Farm Equine 06 Oct, 2021
THE EXAMINATION The standard examination is conducted in either two or five stages, although the exact sequence of the examination may vary. If a two stage is required a disclaimer form will need to be signed and returned previous to the vet attending. The stages are: Stage 1: Preliminary examination This is a thorough external examination of the animal at rest using visual observation, palpation and manipulation to detect clinically apparent signs of injury, disease or physical abnormality. It includes an examination of the incisor teeth, a thorough examination of the horse's eyes in a darkened area and auscultation of the horse's heart and lungs at rest. Examination of the eyes does not include dilating the pupil but should include examination of internal and external structures. The examination DOES NOT include examination of the inside of the prepuce (sheath), a detailed mouth examination with a speculum, a height measurement or any examination for pregnancy. Stage 2: Walk and trot, in hand The animal is walked and then trotted in hand to detect abnormalities of gait and action. Ideally this is carried out on firm, level ground. The horse is turned sharply each way and is backed for a few paces. Flexion tests of all four limbs and trotting in a circle on a firm surface may be carried out if the examining veterinary surgeon considers it safe and appropriate to do so. Stage 3: Exercise phase The horse is usually ridden and given sufficient exercise to: Allow assessment of the horse when it has an increased breathing effort and an increased heart rate. 2. Allow assessment of the horse's gait at walk, trot, canter and, if appropriate, gallop. 3. Allow assessment of the horse for the purpose of stage five. If ridden exercise is not possible for any reason then this stage may be conducted by exercising the horse on a lunge, but this fact should be made clear to the purchaser and on the certificate. Stage 4: Period of rest and re-examination The horse is allowed to stand quietly for a period. During this time the respiratory and cardiovascular systems may be monitored as they return to their resting levels. Stage 5: Second trot up The animal is trotted in hand again to look for any signs of strains or injuries made evident by the exercise and rest stages. Flexion tests Flexion tests and trotting in a circle Flexion tests and trotting in a circle on a firm surface are not mandatory parts of the standard procedure, but they can sometimes provide useful additional information about a horse. There may be circumstances when the examining veterinary surgeon concludes that it is unsafe or inappropriate to perform such tests. Blood Sample Blood Sample A blood sample may be taken for storage (usually for 6 months) for possible future analysis to detect substances present in the horse's system at the time of the examination that might have masked any factors affecting the horse's suitability for the purchaser's intended use. If a blood sample is not taken then the reason should be noted on the certificate. Identification Identification of the horse The horse should be identified by recording the horse's markings in the form of a diagram and written description as well as searching for a microchip and inspecting any available documentation. The diagram may be omitted if the presence of a microchip can be confirmed by scanner and the diagram of an accompanying passport matches the horse. In this instance, both microchip and passport numbers should be recorded on the certificate.
by Home Farm Equine 06 Oct, 2021
As the temperatures begin to rise and the sun starts to shine, regrettably so does the risk presented to the horses caused by Sycamore seedlings and seeds. Eating these can cause Seasonal Pasture Myopathy (previously known as Aytypical Myopathy / Sycamore poisoning). This condition has a very sudden in onset, with clinical signs consisting of: stiffness, reluctance to move, muscle tremors, sweating, weakness, lethargy, difficulty in breathing, reluctance to work, red or brown urine, choke, colic, low head carriage, fast or irregular heartbeat and sudden collapse. The time from the onset of symptoms to collapse can be as short as 24 hours. The helicopter shaped seeds are now springing up as seedlings, which are also poisonous. We would advise pulling up all seedlings before allowing horses to graze any affected pasture. Seeds can travel up to 200metres from the tree, especially in the winds we have been experiencing lately, so please be vigilant. Seedlings, seeds and leaves of Sycamore trees can be tested for the toxin Hypoglycin A, which causes SPM. The Royal Veterinary College, London is carrying out this testing. http://www.rvc.ac.uk/research/laboratories/comparative-neuromuscular-diseases-laboratory/diagnostic-services#panel-n-e-w-atypical-myopathy-testing If your horse shows any of these signs, or you are worried after grazing near sycamore trees, please call us immediately on 0115 9899411 .
by Home Farm Equine 06 Oct, 2021
When to castrate? Most horses are castrated as yearlings, however anytime after 6months is acceptable providing both testicles have descended. When colts mature into stallions, and they reach 2 years old, the testicles become much larger and have bigger blood vessels which make the castration procedure more difficult as they require ligation (tying off) of these vessels. It is normal to try and avoid the fly season from May to October as the castration wounds are left open and do attract flies which is a major cause of post castration infection. How to castrate? Well-handled colts up to 18months old can usually be castrated standing with heavy sedation. However, if they are likely to kick or have unusually large testicles they will need to be “knocked down” and given a short general anaesthetic (GA) which makes the process safer for all concerned and allows the vet to tie off the large testicular blood vessels. The process usually takes 15 minutes and then a further 15-30 minutes for the horse to stand up again. An area of flat, clean grass or a school surface is required. Post castration care Routine care is simple but essential and without these complications are very common. The castration site wounds are always left open to allow the post–op swelling fluid to drain away. The removal of the testicles leaves a cavity which has to fill in and heal from the inside; this process produces inflammatory fluid which must be allowed to drain. It is ESSENTIAL that the wound is hosed TWICE daily for 5 minutes and a scab, if present, is wiped away (with some cotton wool in dilute Savlon or Hibiscrub) to stop the scrotal skin edges sticking together and trying to heal and close. The wound must be kept open for at least a week. Failure to do this will allow the wound to close too soon and a large fluid swelling at the site and swelling of the sheath will occur. This will then require the vet to visit and reopen the site and put the horse on a course of antibiotics. It is very important that the horse is turned out to EXERCISE as this will reduce the amount of swelling of the sheath. Even with exercise it is normal for the sheath to swell to half a honey melon size. We normally recommend that the colts are turned out the same day as the castration, but adult stallions are turned out the day after castrate. Tetanus cover is essential and if not vaccinated it will need an anti toxin injection to give immediate protection. Pain relief is recommended with “bute” given twice daily for 5-7 days. Antibiotics are not routinely given as these surgeries are left open to drain and thus are not required. Although castrations are considered to be a very routine procedure it must be remembered that in the horse they are a relatively major surgical operation with potential fatal complications such as haemorrhage and evisceration of small intestine through the surgical wound. These complications can be reduced to almost “theoretical” providing the correct techniques are used in relation to the size, age and type of male horse being treated. For owners the mainstay of care is thorough cold hosing and cleaning of the wound for at least a week and providing good clean turnout exercise. Contact with mares should be avoided for one month. If you have any further questions, please do not hesitate to contact us on 0115 989 9411.
by Home Farm Equine 06 Oct, 2021
The following information will cover points on the following: Wounds Colic Lameness Choke WOUNDS LOCATION OF THE WOUND Wounds on the leg sheath/joints on the fore and hind legs need an examination. The horse may be acutely lame with a tendon sheath/joint infection. THIS IS A TRUE EMERGENCY AND A VET MUST BE CALLED AS SOON AS POSSIBLE
by Home Farm Equine 06 Oct, 2021
Veterinary Acupuncture is a complementary treatment that is increasingly being recognised as a useful treatment for a wide range of conditions. It should be stressed that the term “complementary” is the correct term for the use of veterinary acupuncture, as this therapy complement our conventional veterinary care. It is an adjunct, not a replacement, although in some situations it can be used as a sole treatment.
by Home Farm Equine 06 Oct, 2021
What is Cushing Disease? The average age of horses with Equine Cushing disease is 19 years old with a range of 7 to 40 years. There is no sex predisposition but ponies appear to develop the disease more frequently.
by Home Farm Equine 06 Oct, 2021
Parasite Control in Horses Horses can become infected with both ectoparasites (lice and mites) and endoparasites (worms). The effect of a parasite infection on the horse's health depends on the number and type of parasite involved. Generally, the higher the parasite burden, the higher the risk of clinical disease. 
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